Ketamine Therapy for Depression in Chattanooga, TN

When antidepressants haven’t worked — or stopped working — ketamine offers a fundamentally different mechanism, with relief that can arrive within 24 hours.

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How It Helps

How Ketamine Helps Depression

Roughly one in three people with depression doesn’t respond to conventional antidepressants. Ketamine works differently: instead of slowly adjusting serotonin levels, it triggers a glutamate surge that releases BDNF and rapidly regrows the synaptic connections depression erodes. How MSKIT® works →

In a randomized controlled trial published by the National Library of Medicine, patients receiving a single ketamine infusion improved significantly more than the active-placebo group within 24 hours — a 7.95-point greater drop on the MADRS depression scale (see the study). In our own 2022–2024 research across 252 patients, MSKIT® showed an 82% response rate — more on our research page.

Sound Familiar?

Signs This Treatment May Be For You

  • ✓You’ve tried two or more antidepressants without lasting relief
  • ✓Side effects made medications hard to stay on
  • ✓Therapy helps, but the floor keeps dropping out from under it
  • ✓Anhedonia — nothing feels worth doing anymore
  • ✓Depression is costing you work, relationships, or safety

If several of these ring true, a free consultation is the fastest way to know for sure — here’s exactly what happens when you reach out.

What to Expect

Your Treatment Journey

  • ✓Free consultation — a provider reviews your history and confirms ketamine is appropriate. New patients: start here →
  • ✓Stabilization Phase — a series of CRNA-administered infusions in a calm, private room over 2–3 weeks. See the full process →
  • ✓Outcome tracking — your progress is measured in the Osmind app throughout treatment and beyond. Why we measure everything →
  • ✓Success Plan & boosters — a Post-Stabilization Success Plan meeting, then single boosters only as needed. Transparent pricing →

Protocol & Pricing

The Protocol We’d Likely Recommend

$2,400

Mood Disorder Protocol

Six 40-minute infusions with NAD+ adjuncts, Osmind tracking, and a Post-Stabilization Success Plan meeting. $2,400 paid in full or $2,500 with a 0% interest plan; $395 boosters as needed.

Full pricing & payment options →

Ways to Pay

FSA/HSA pre-tax dollars, CareCredit financing, VA Community Care coverage for veterans, and SCN Service Program pricing for law enforcement and first responders.

SCN Service Program →

Why Scenic City Neurotherapy

Numbers We Publish. A Team You Can Meet.

27,000+infusions delivered since 2019About the clinic →
82%response rate · 252-patient study (2022–2024)Our approach →
100%CRNA-administered infusionsMeet the team →
4.9 ★across 84 Google reviewsPatient stories →

“Everybody needs beauty as well as bread, places to play in and pray in, where nature may heal and cheer.”

— John Muir

Your Questions, Answered

Depression FAQs

How fast does ketamine work for depression?+

Many patients notice improvement within 24 hours of their first infusion, with effects building across the six-infusion Stabilization Phase. Published randomized controlled research documents measurable improvement in depression severity within 24 hours of a single infusion.

What if I’ve already failed multiple antidepressants?+

That is exactly who ketamine helps most. It bypasses the serotonin system entirely, acting on glutamate and BDNF to rebuild neural connections — which is why it works for treatment-resistant depression.

Should I consider TMS instead?+

TMS is FDA-cleared for treatment-resistant depression and drug-free, with 90%+ response using our SNT and ONE-D protocols; ketamine acts faster and also treats pain and PTSD. Many patients benefit from both — your free consultation determines the right path.

Will I have to stop my current antidepressant?+

Usually no — most antidepressants can continue during ketamine treatment. Bring your medication list to consultation; our CRNAs review everything and coordinate with your prescriber.

Keep Exploring

Related Conditions & Reading

AnxietyPTSDOCDSuicidal IdeationChronic PainPost-Op & InjuryMigraineLong-COVID

Deeper reading: the research library · articles from our providers · all FAQs

We treat patients from across the region:

Whitewater on the Ocoee River near Cleveland, TNCleveland, TNChickamauga Dam on the Tennessee River near Hixson, TNHixson, TNHistoric James County Courthouse in Ooltewah, TNOoltewah, TNThe Sunsphere in downtown Knoxville, TNKnoxville, TNTrain passing through downtown Dalton, GADalton, GAThe historic 1850 Ringgold Depot in Ringgold, GARinggold, GAThe Birmingham, AL skylineBirmingham, AL

Hear It From a Patient

Tracy’s Story: Overcoming Treatment-Resistant Depression

Tracy shares her inspiring journey overcoming treatment-resistant depression with Transcranial Magnetic Stimulation at Scenic City Neurotherapy.

More patient stories →

Tracy shares her treatment-resistant depression recovery story — video testimonial1:59

Take the First Step Today.

Tell us a little about what you’re facing. A provider — not a salesperson — will reach out within one business day.

(423) 228-0579
  • ✓Free, confidential, no obligation — a provider answers your questions
  • ✓We respond within one business day
  • ✓Veterans: we handle VA Community Care referrals with you

Prefer to visit first? Take the Google office tour · 7405 Shallowford Rd, Suite 240, Chattanooga, TN

Free & confidential

Request a Free Consultation

A provider — not a salesperson — will reach out within one business day.

Prefer to talk? (423) 228-0579