ONE-D: Depression Treatment in a Single Day

20 iTBS treatments, one day, plasticity priming, 90%+ patient-reported response. Developed by AMPA — and it’s here in Chattanooga.

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The Breakthrough

Why Compress Six Weeks into One Day?

Traditional rTMS spreads 36 sessions across six weeks — effective, but a long commitment when you’re struggling. ONE-D delivers 20 intermittent theta-burst (iTBS) treatments in a single day, one every 30 minutes over about 9.5 hours, paired with plasticity priming that prepares your brain to respond.

Developed by AMPA, the ONE-D protocol is transforming depression care — making it faster, more effective, and more accessible than ever before. It’s especially suited to patients who travel to reach us, can’t step away from work or caregiving for six weeks, or need momentum now.

  • ✓20 iTBS treatments in one day — one every 30 minutes over 9.5 hours
  • ✓Paired with plasticity priming for maximum receptivity
  • ✓Over 90% patient-reported response rate
  • ✓$2,500 — with financing and HSA/FSA options available

Your Day

What the Day Looks Like

Morning

Arrive, settle in, and complete plasticity priming. Your 3D Stim-Guide mapping (done in advance) targets every pulse precisely.

Through the Day

Brief iTBS sessions every 30 minutes — each just minutes long — with comfortable rest, meals, and quiet time in between.

Evening

You head home the same day, no sedation, no downtime — with follow-up outcome tracking already scheduled.

How It Works

Plasticity Priming, Then Precision Stimulation

Conventional TMS spreads its course over weeks of clinic visits. ONE-D is the first reported protocol to achieve remission from treatment-resistant depression in a single day of treatment using an FDA-cleared device.

iTBS targets the left dorsolateral prefrontal cortex, sending pulses that activate the underperforming networks responsible for motivation and emotional balance. Over the course of the day, this rewires the brain toward healthier patterns.

Patient outcomes are our first priority, which is why we chose the most advanced FDA-approved rTMS system offering neuronavigation — ensuring precise coil positioning at every session of the day. TMS itself has been researched for over 30 years and received FDA approval in the U.S. in 2008 for major depressive disorder in adults who did not find relief from medications.

Independent peer-reviewed results for the ONE-D regimen are published in the Transcranial Magnetic Stimulation journal and sit among the research we share with referring providers. Figures quoted elsewhere on this page are our own patient-reported outcomes and may differ from published trial data.

Is It Right for You

Who ONE-D Fits Best

Treatment-resistant depression

Adults who have not improved with medication often benefit from TMS. ONE-D was designed for patients who previously faced 90 days of treatment to get there.

Out-of-town patients

We are just off I-75 with easy access from Nashville, Knoxville, Atlanta, and Charlotte, and 10–15 minutes from Chattanooga Metropolitan Airport. See our out-of-town patient guide.

Not sure which protocol fits? Compare all three TMS paths or speak with our clinical team — the consultation is free and you will get a straight answer.

Compared To

ONE-D, SNT, or Classic rTMS?

All three protocols are available here, and the right one is the one you can actually complete. Across both accelerated protocols, our patients report 90% or greater remission of depressive symptoms.

ONE-D — one day

  • ✓20 iTBS sessions in 9.5 hours
  • ✓Begins with plasticity priming
  • ✓Over 90% response rate
  • ✓Best for tight schedules and travel

iTBS / SNT — five days

  • ✓10 sessions a day for 5 days
  • ✓50 sessions total
  • ✓Region’s only provider
  • ✓Three ketamine boosters built in

Classic rTMS — nine weeks

  • ✓One session a day, Mon–Fri
  • ✓36 sessions over 6 weeks + 3-week wean
  • ✓Sessions about 20 minutes
  • ✓Insurance-reimbursable

TMS also bypasses the common side effects of antidepressants, and you can achieve long-term relief without the shock or seizure induction involved in ECT. See TMS pricing.

Cost & Coverage

Paying for ONE-D

ONE-D is $2,500 — an entire treatment course in one day. Transcranial Magnetic Stimulation is insurance-reimbursable, and we help patients navigate that process.

  • ✓Scenic City Neurotherapy is a contracted VA Community Care Network provider — veterans with a VA referral are eligible for coverage on both TMS and ketamine therapy
  • ✓Special pricing for law enforcement, veterans, and first responders
  • ✓Flexible payment options through CareCredit
  • ✓The SCN Service Program offers scholarships for those who qualify

See full TMS pricing · Learn about the SCN Service Program

Common Questions

ONE-D Protocol FAQ

How long does the ONE-D treatment day last?

The protocol delivers 20 iTBS sessions across 9.5 hours — one session every 30 minutes. You are with us for the full day and go home the same evening.

What are the response rates for ONE-D?

ONE-D achieves over 90% response rates. At Scenic City Neurotherapy, patients report 90% or greater remission of depressive symptoms when completing TMS using either the SNT or the ONE-D approaches.

Who is a good candidate for ONE-D?

Adults with treatment-resistant depression who have not improved on medication often benefit from TMS. Because ONE-D compresses an entire course into one day, it particularly suits people who cannot commit to six weeks of daily visits or who are traveling in for care. Speak with our clinical team to confirm you are a good fit.

Does ONE-D hurt? Is there downtime?

Most people feel a tapping sensation on the scalp during treatment and have no downtime afterward. There is no anesthesia, no sedation, and no seizure induction as there is with ECT.

How is ONE-D different from the SNT protocol?

Both are accelerated iTBS protocols and both report greater than 90% remission of depressive symptoms. SNT delivers 10 sessions per day across five consecutive days (50 sessions); ONE-D delivers 20 sessions in a single day, beginning with plasticity priming.

Is ONE-D covered by insurance?

Transcranial Magnetic Stimulation is insurance-reimbursable and we help patients navigate that process. Scenic City Neurotherapy is also a contracted VA Community Care Network provider — veterans with a VA referral are eligible for coverage on both TMS and ketamine therapy. We offer special pricing for law enforcement, veterans, and first responders.

What technology do you use?

We chose the most advanced FDA-approved rTMS system offering neuronavigation, which ensures precise coil positioning at every treatment. TMS received FDA approval in the U.S. in 2008 for major depressive disorder in adults who did not find relief from medications, and has been researched for over 30 years.

One day. A different trajectory.

Take the First Step Today.

Tell us a little about what you’re facing. A provider — not a salesperson — will reach out within one business day.

(423) 228-0579
  • ✓Free, confidential, no obligation — a provider answers your questions
  • ✓We respond within one business day
  • ✓Veterans: we handle VA Community Care referrals with you

Prefer to visit first? Take the Google office tour · 7405 Shallowford Rd, Suite 240, Chattanooga, TN

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A provider — not a salesperson — will reach out within one business day.

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